Preimplantation Genetic Testing for Monogenic Disorders, or PGT-M, is a genetic test performed before pregnancy to significantly reduce the risk of having a child with a specific genetic disease.

Introduction to PGT-M

PGT-M is performed in conjunction with IVF and is appropriate when a known genetic mutation exists within a family.

Introduction to PGT-M

PGT-M is performed with serial PGT-A testing on unaffected and carrier embryos to reduce the risk of both single gene disorders and chromosome abnormalities.

PGT-M Icon Who Should Consider PGT-M?

PGT-M may be appropriate for:

  • Couples who are carriers of the same autosomal recessive condition
  • Carriers of X-linked conditions
  • Individuals with autosomal dominant conditions
  • Carriers of mutations associated with hereditary cancer syndromes

Genetic counselling is required before proceeding.

Speak to a Genetic Counsellor

Who should consider PGT-M?

How the PGT-M Process Works

The full process may take several months depending on complexity.

Step 1

Genetic counselling and case review

Step 2

Collection of DNA samples from relevant family members

Step 3

IVF cycle and embryo biopsy

Step 4

Custom test design, and laboratory testing of embryo biopsy samples typically 4 to 6 weeks

Step 5

Results released to your fertility clinic

Frequently Asked Questions

Find answers to common questions about PGT-M:

Embryo biopsy has not been shown to increase health risks in children born following IVF when performed appropriately.

No test can guarantee a child will not have medical issues. PGT-M tests specifically for the known familial genetic condition and does not screen for unrelated conditions.

No, unfortunately medical aids do not currently cover PGT-M.