What Is POCScreen?
More than half of first-trimester miscarriages are caused by chromosomal abnormalities.1
The POCScreen test offered by Next Biosciences employs next generation sequencing technology to rapidly and accurately screen products of conception for abnormal chromosome numbers, and large genetic deletions and/or duplications of chromosomal material.
The test aims to give patients answers after a loss and provide healthcare providers with information for reproductive counselling.
Benefits of POCScreen Testing
POCScreen provides both clinical and emotional value by:
Fast result turnaround time (7-10 working days)
No need for cell culturing
Test is done on next generation sequencing technology which ensures high resolution results
Allows for the detection of all chromosomes, as well as, large duplications and deletions
Accurately detects unbalanced translocations >20Mb
Pick-up rate of approximately 50%2
Who Should Consider POCScreen?
POCScreen may be recommended for:
- Couples who have experienced a pregnancy loss
- Individuals with recurrent miscarriages
- Patients seeking answers and clarity after miscarriage
- Healthcare providers needing information for reproductive counselling
Technology
Next Biosciences uses next generation sequencing to rapidly and accurately screen Products of Conception (POC) for chromosomal abnormalities.
- >99% analytical specificity3
- >99% diagnostic accuracy3
- >99% analytical sensitivity3
- Test failure rate of 0.1% 2
Methodology
Sample assessment
DNA extraction
Whole genome amplification
Library preparation
Next generation sequencing
Results and report generation
How POCScreen Works
Healthcare provider completes the Test Requisition Form (TRF)
Sample is collected from pregnancy tissue
Sample and TRF are sent to Next Biosciences
DNA sequencing (NGS) is performed
Results are available within 7–10 working days
References
- Choi TY, Lee HM, Park WK, Jeong SY, Moon HS. Spontaneous abortion and recurrent miscarriage: A comparison of cytogenic diagnosis in 250 cases. Obstet Gynecol Sci. 2014 Nov,57(6):518-525.
- Next Genetics Products of Conception Statistics January 2020 – December 2020, data available upon request.
- POC in house validation study, data available upon request.